Ctgf tumor

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August undefined, 2024

WebSep 9, 2015 · High expression of CTGF in breast tumor epithelial component correlates with poor clinical prognosis and outcomes. The interaction between tumor and stromal cells … WebMar 3, 2004 · Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells, but few mechanistic details are known. We investigated the roles of CTGF and collapsin response mediator protein 1 (CRMP-1) in metastasis and invasion of human lung adenocarcinoma.

Targeting CTGF in Cancer: An Emerging Therapeutic Opportunity

WebConnective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. ... CCN2 inhibits lung cancer … WebAug 8, 2024 · Lai, D., Ho, K. C., Hao, Y. & Yang, X. Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res ... binding experience

Expression of epithelial–mesenchymal transition-associated …

WebJun 15, 2012 · Therefore, we investigated whether CTGF modulates metabolism in the tumor microenvironment. For this purpose, CTGF was overexpressed in normal human fibroblasts or MDA-MB-231 breast cancer cells. Overexpression of CTGF induces HIF-1α-dependent metabolic alterations, with the induction of autophagy/mitophagy, … WebApr 20, 2016 · Breast cancer is the most common cancer in women worldwide, and approximately 90% of breast cancer deaths are the result of metastasis. Metastasis is the process by which tumor cells detach from a primary tumor and migrate to nearby blood vessels or the lymph system, and are thereby able to spread to other organs in the host … WebCCN (for CYR61/ CTGF /NOV) proteins were identified originally from diverse cellular contexts and studied for their growth-promoting activities. It is now known that there are … cystio

The reactive tumor microenvironment: MUC1 signaling directly …

Efficiency of Promoters of Human Genes FAP and CTGF at …

WebMar 31, 2011 · These studies suggest that Cyr61 and CTGF are 2 critical TAZ transcriptional targets mediating TAZ-induced drug resistance in breast cancer cells. Together, our studies provided the first biological evidence that overexpression of the TAZ oncogene can cause drug resistance of breast cancer cells through direct activation of 2 secreted and ... WebWe examined in detail the molecular mechanisms of MUC1.CT signaling that induces the expression of connective tissue growth factor (CTGF/CCN2), a potent mediator of ECM … bindingexpression path error:WebSep 1, 2024 · Connective tissue growth factor (CTGF) is a matricellular protein related to hepatic fibrosis. This study aims to clarify the roles of CTGF in hepatocellular carcinoma … binding expression

"WebAug 6, 2024 · Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis. ... cancer, and infections. Glomerulonephritis is a common cause of end-stage renal failure. Severe and prolonged inflammation can … " - Ctgf tumor

Ctgf tumor

CTGF enhances resistance to 5-FU-mediating cell apoptosis …

WebOf late, there is accumulating evidence that CTGF expression is highly correlated with the development of cancers. 5 Elevated CTGF expression has been observed in mammary … WebCTGF expression has been tied in with tumor growth, invasion, and metastasis. It shows aberrant expression in many forms of cancer, such as prostate, breast, and esophageal …

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WebSep 9, 2015 · High expression of CTGF in breast tumor epithelial component correlates with poor clinical prognosis and outcomes. The interaction between tumor and stromal cells and their signaling output mould the microenvironment to support tumorigenesis and metastasis [].In this context, cytokines, chemokines, as well as growth, angiogenesis and … WebSep 4, 2024 · Connective tissue growth factor (CTGF) is a matricellular protein related to hepatic fibrosis. This study aims to clarify the roles of CTGF in hepatocellular carcinoma (HCC), which usually develops from fibrotic liver. CTGF was overexpressed in 93 human HCC compared with nontumorous tissues, primarily in tumor cells.

WebJul 12, 2014 · Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth … WebJul 27, 2024 · In this AM dataset, we annotated a new subcluster of fibroblasts, CTGF + CAFs, which might be a key factor in AM tumor occurrence and metastasis. CTGF + CAFs act on malignant cells …

WebJul 8, 2013 · Accordingly, we investigated the function of connective tissue growth factor (CTGF), a protein known to be important in stromal formation. CTGF is a pleiotropic and cysteine-rich matricellular protein that is abundant in many solid malignancies including pancreas, breast, esophageal, glioblastoma, and hepatocellular carcinoma ( 18 – 23 ). WebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple …

WebSep 15, 2024 · Malignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid progression and resistance to standard therapeutic modalities such as surgery, chemotherapy, and radiotherapy. Our previous studies have suggested that tumor cell-derived connective tissue growth …

WebFeb 2, 2014 · Here, we define connective tissue growth factor (CTGF) as a therapeutic target for metastatic melanoma. Clinically, CTGF expression correlates with tumor progression and is strongly induced by hypoxia through HIF-1 and HIF-2-dependent mechanisms. Genetic inhibition of CTGF in human melanoma cells is sufficient to … bindingexpression.updatesourceWebMay 10, 2024 · Our findings suggest that CTGF is a marker for medulloblastoma independent of molecular subgroups and its transcriptional program is active at the … cyst in your eyeWebAug 27, 2014 · (A) Fibroblasts were purified from Myc-CaP tumors 1 wk after sham operation or castration (C) (n = 10 per group), plated, and stimulated for 24 h with TGF-β1 (10 ng/mL), CTGF (50 ng/mL), or TGF-β1 plus CTGF. RNA was isolated, and expression of the indicated genes was analyzed as described earlier. binding export beerWebIncreasing evidence emphasizes the notion that CTGF is pivotal in cancer initiation and progression. The interplay of tumor cells and the tumor microenvironment significantly … binding experimentsWebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the … cystiphane forumWebMar 10, 2024 · CTGF is overexpressed in triple-negative breast cancer. In a publicly available gene expression database, the Cancer Cell Line Encyclopedia portal, we … binding expression in javascriptWebJun 3, 2013 · Background The role of CTGF varies in different types of cancer. The purpose of this study is to investigate the involvement of CTGF in tumor progression and prognosis of human nasopharyngeal carcinoma (NPC). Experimental design CTGF expression levels were examined in NPC tissues and cells, nasopharynx (NP) tissues, and NP69 cells. The … bindingexpression updatesource