Shoc2 ihc

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August undefined, 2024

WebAnti-SHOC2 antibody produced in rabbit Synonym (s): Anti-Leucine-rich repeat protein SHOC-2, Anti-Ras-binding protein Sur-8, Anti-SOC2, Anti-Leucine-rich repeat protein SHOC-2 … WebMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human SHOC2 protein. …

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Web1 Dec 2015 · The scaffold protein Shoc2 tethers Ras, RAF-1 and the catalytic subunit of protein phosphatase 1c (PP1c, also known as PPP1CA) to accelerate ERK1/2 signals (Rodriguez-Viciana et al., 2006).Silencing of Shoc2 expression leads to a dramatic decrease in ERK1/2 activity in a myriad of cells and in C. elegans (Rodriguez-Viciana et al., 2006; … WebBiological assembly of SHOC2 protein as shown by crystal structure to a resolution of 2.4 Angstrom. Sulfate molecules are labeled purple. Structure from 10.2210/pdb7TVG/pdb. … fix chain pop on razor e 175 scooter

SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in

WebSHOC2 (soc-2 suppressor of clear homolog) (eg, Noonan-like syndromewith loose anagen hair), S2G variant 81400-32 81400-33 SMN1 (survival of motor neuron 1, telomeric) (eg, spinal muscularatrophy), exon 7 deletion 81400-34 81400-35 81401-01 81401-03 81401-05 WebTherapeutic potential of SHOC2 via its selective contribution of the ERK pathway activation Isabel Boned del Río Submitted in fulfilment of the requirements for the Degree of Doctor of Philosophy University College London 2024. 2 Declaration Web13 Jul 2024 · SHOC2 Ile173 (Met173 in WT SHOC2) fills a hydrophobic space produced by SWI, SWII and SHOC2 LRR domains. SHOC2 Gln269/His270 resides at the interface of all … fix chain vertical blinds

Therapeutic potential of SHOC2 via its selective contribution of …

Anti-SHOC2 Antibody ABS461

WebBiological assembly of SHOC2 protein as shown by crystal structure to a resolution of 2.4 Angstrom. Sulfate molecules are labeled purple. Structure from 10.2210/pdb7TVG/pdb. SHOC2 protein leucine rich domain. Leucine amino acids shown as bright orange sticks. WebYour search returned 219 Shoc2 Antibodies across 28 suppliers. Showing 28 of 28 suppliers (219 products total) ... Applications: WB, ELISA, ICC, IF, IHC-fr, IHC-p; Reactivity: Hu, Ms, … can lower back pain cause shoulder painWebSulahian, Kwon, and Walsh et al. performed several loss-of-function CRISPR-Cas9 screens in KRAS-mutant cancer cells treated with a MEK inhibitor and define the landscape of modifiers of MEK inhibitor sensitivity while highlighting that SHOC2 is a potent synthetic lethal target that serves as a critical signaling node to mediate MAP kinase pathway reactivation upon … fix chain link fence gapping

"Web5 Nov 2024 · Studies over the past decade have uncovered the critical role of the Shoc2 scaffold in the transmission of signals through the core ERK1/2 cascade (Jang et al., 2024).These studies convincingly demonstrated that this seemingly auxiliary component of the ERK1/2 signaling network is an indispensable regulator of the ERK1/2 pathway, as its … " - Shoc2 ihc

Shoc2 ihc

Webanti-SHOC2 Antibody reacting with Rabbit and identified with ELISA, WB, IHC, IF. Quality is guaranteed. Call: 301-363-4651; Email: [email protected] All. All; ELISA Kit; Protein; Antibody; Molecular Biology Product; Small Molecule; ... All lanes: SHOC2 antibody at 3μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted ... WebFull gene name according to HGNC. SHOC2 leucine rich repeat scaffold protein. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to …

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WebAll Deafness, congenital, unilateral or asymmetric; DEEAH syndrome . All DEEAH syndrome; Primary Antibodies Web4 Feb 2024 · DOI: 10.1038/s41594-022-00841-4. Primary Citation of Related Structures: 7TVF, 7TVG. PubMed Abstract: SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by ...

Web21 Jun 2013 · Shoc2 is a positive regulator of signaling to extracellular signal-regulated protein kinases 1 and 2 (ERK1/2). Shoc2 is also proposed to interact with RAS and Raf-1 in order to accelerate ERK1/2 activity. To understand the mechanisms by which Shoc2 regulates ERK1/2 activation by the epidermal growth factor receptor (EGFR), we dissected … Web丁香通为您提供紧密连接蛋白5抗体商品详情介绍：价格：￥1317.60 - 3480，货号：iaa00541，品牌：mbc，产地：中国，详见丁香通紧密连接蛋白5抗体商品详情页；

WebIn addition, we confirmed that SHOC2 expression levels were important for the sensitivity to EGFR–TKIs in vivo. Furthermore, IHC showed the accumulation of cancer cells that … WebWe offer a wide range of validated Shoc2 / Sur8 antibodies. 24 hour response to all enquiries. ️ High Quality Products ️ Low Prices ️ 100% Guarantee Useful Links 01223 298 875

WebThese data indicate that SHOC2 may be a therapeutic target for patients with NSCLC or a biomarker to predict sensitivity to EGFR-TKI therapy in EGFR mutation-positive patients …

WebIHC; 1 /2. Western blot analysis of extracts from U-251 cells, using Sur-8 Antibody. DF12234 at 1/100 staining Rat liver tissue by IHC-P. Previous Next. 产品: fix chair with cushion fallingWebSHOC2 Rabbit anti-Human Polyclonal Antibody Reactivity: Mouse, Rat, Human Applications: IHC, Peptide-ELISA, WB Format: Unconjugated Price: 100 µl/$379; 200 µl/$421 Select … can lower back pain cause upset stomachWeb7.1 SHOC2 is required for MEKi-induced feedback relief RAF dimerization and ERK-activation 108 7.1.1 Introductory statement 108 7.1.2 SHOC2 deletion impairs rebound MEK phosphorylation by Selumetinib in H358 cells in both a dose and time-dependent manner. 108 7.1.3 SHOC2 is required for MEKi-induced feedback relief ERK-activation 110 can lower back pain make you dizzyWebSHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF NTpS 11-13, but the structure of SHOC2 and the architecture of the presumptive SHOC2-PP1C-RAS complex remain unknown. Here we present a cryo-electron microscopy structure of the SHOC2-PP1C-MRAS complex to an overall resolution of 3 Å, … fix chalky silicone phone caseWeb21 Nov 2024 · Shoc2 activates ERK1/2 to promote tumor development through regulation of contact inhibition and cell polarization . Kaduwal et al. confirmed that Shoc2 regulates motility, invasion, and metastasis of cells through activation of the ERK and PI3K pathways. These results indicated that Shoc2 might play an important role in tumorigenesis and that ... fix charge ratioWebSur8/Shoc2 is a scaffold protein that regulates the Ras-extracellular signal-regulated kinase (ERK) pathway. However, the roles of Sur8 in cellular physiologies are poorly understood. In this study, Sur8 was severely repressed in the course of neural progenitor cell (NPC) differentiation in the cerebral cortex of developing rat embryos. can lower back pain cause stomach problemsWeb20 Jun 2001 · Function. Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS … fix chain link gate